"Unlocking Tomorrow's Health Today."
Nugene Health consulting is the pioneer in Genetic Diagnosis in the field of Reproductive Genetics and Ontogenetic in north India. From introducing prenatal genetic screening and diagnosis to cutting edge cancer genetics program, Nugene has always been ahead of the curve.
We are following the guidelines and protocols set by internationally renowned organizations like Fetal Medicine Foundation (U.K.) & National Health Service (U.K.) in North India and successfully shape the genetic screening and diagnostics industry of the country.
NUGENE have high-end cancer genetic testing panels in the disease areas of Solid Tumors, Hematological Malignancies and Sarcomas which helps for the appropriate prognostication of the disease thereby help to choose the appropriate treatment decision on standard chemotherapy, targeted therapy, immunotherapy or palliative care.
Genomics: Genomics is an interdisciplinary field of molecular biology that focuses on the structure, function, evolution, mapping, and editing of genomes—complete sets of DNA including all genes and their three-dimensional configurations. Unlike genetics, which studies individual genes and their roles in inheritance, genomics aims to collectively characterize and quantify all genes in an organism, exploring their interrelations and overall influence. This field encompasses sequencing and analyzing genomes using high-throughput DNA sequencing and bioinformatics to understand the function and structure of entire genomes. Advances in genomics have revolutionized discovery-based research and systems biology, facilitating a deeper understanding of complex biological systems, such as the brain.
- NGS : This advanced sequencing technology enables the rapid and high-throughput analysis of DNA sequences, facilitating the detection of various genetic variations and mutations.
- Microarray : Microarray analysis detects chromosomal copy number variations (CNVs) and can identify smaller genetic deletions or duplications that may not be visible with traditional karyotyping.
Reproductive genetic screening: Reproductive genetic screening refers to a set of tests and procedures aimed at identifying genetic abnormalities or mutations in individuals or couples who are planning to have children or already pregnant. These screenings can help assess the risk of passing on genetic disorders to offspring and enable informed decisions about family planning, including the consideration of options like preimplantation genetic diagnosis (PGD), prenatal testing, or adoption.
Genetic screening encompasses a range of tests and techniques aimed at assessing genetic information:
- Markers : NUGENE FTS, NUGENE QUARD, bio chemical hormonal screening throw FMF accredited platform which every pregnant woman want to her personal accurate risk which will she decide accept or reject invasive processor (cvs and amniocenteses).
- PGT/PGS : (Preimplantation Genetic Testing/Screening): PGT involves the testing of embryos created through in vitro fertilization (IVF) to detect genetic abnormalities before implantation, aiding in the selection of embryos free from certain disorders.
- NIPS (Non-Invasive Prenatal Screening : This screening method analyzes cell-free fetal DNA present in the maternal bloodstream to evaluate the risk of chromosomal abnormalities, such as Down syndrome, in the fetus.
- Karyotyping :This technique examines the entire set of chromosomes to identify numerical and structural abnormalities, such as extra or missing chromosomes, or chromosomal rearrangements.
- Microarray :Microarray analysis detects chromosomal copy number variations (CNVs) and can identify smaller genetic deletions or duplications that may not be visible with traditional karyotyping.
- SANGER SEQUENCING :A method used to determine the exact sequence of nucleotides in a DNA molecule, often employed for identifying specific genetic mutations.
- NGS (Next-Generation Sequencing):This advanced sequencing technology enables the rapid and high-throughput analysis of DNA sequences, facilitating the detection of various genetic variations and mutations.
Ontogenetic: Ontogenetic is the study of genetic factors contributing to cancer development, utilizes various sophisticated testing methods:
- PCR-Based Tests: : Polymerase Chain Reaction (PCR) based tests are instrumental in amplifying specific DNA sequences associated with oncogenes or tumor suppressor genes. This amplification facilitates the detection of mutations or abnormalities linked to cancer development with high sensitivity and specificity.
- RT-PCR Based Tests: Reverse Transcription Polymerase Chain Reaction (RT-PCR) based tests are particularly valuable for assessing gene expression levels in cancer cells. By converting RNA into complementary DNA (cDNA) and then amplifying specific sequences using PCR, RT-PCR allows for the quantification of gene expression, aiding in the identification of over expressed or under expressed ontogenesis or tumor suppressor genes. Example: BCR-ABL1, PML-RARA, ALL, EGFR, JAK2, KRAS, NRAS etc.